Chlorthalidone

(klor thal' i done)

 

PContraindicated In Pregnancy - Contraindicated in pregnancy

LContraindicated in lactation - Contraindicated in lactation

Molecule Info

 

Indication & Dosage

Oral  Hypertension  Adult: 25 mg daily given alone or with other antihypertensives, increased to 50 mg daily if necessary.  Child: 2 mg/kg/day or on alternate days. Oral  Oedema  Adult: Initially, 25-50 mg daily up to 100-200 mg daily in severe cases.  Maintenance: 25-50 mg daily or on alternate days. Oral  Diabetes insipidus  Adult: Initially, 100 mg bid reduced gradually.  Maintenance: 50 mg daily.

Contraindications

Severe renal impairment or anuria.  Severe hepatic impairment, addison's disease, preexisting hypercalcaemia, asthma; hypersensitivity; severe allergy.  Pregnancy and lactation.

Special Precautions

Existing fluid and electrolyte disturbances, hepatic cirrhosis, severe heart failure, hyperuricaemia, mild to moderate renal impairment.  Elderly.  Monitor fluid and electrolyte balance.  Kidney or liver disease; diabetes; gout; hyperlipidaemia and ventricular extra systoles.

Adverse Drug Reactions

Dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, seizures, oliguria, hypotension, fatigue, muscle cramps and GI disturbances, nausea, vomiting, constipation, diarrhoea, anorexia.  Diabetes and gout may be precipitated.  Impotence.  Raised blood levels of glucose, urates, lipids and calcium.  Reduced levels of K and magnesium.  Raised CPK levels. Potentially Fatal: Rare.  Severe hyponatraemia and idiosyncratic hypersensitivity.

Drug Interactions

NSAIDs antagonise hypotensive action.  Suppresses action of Oral   anticoagulants due to reduced prothrombin activity.  Increased risk of hypokalaemia when corticosteroids are given concurrently. Potentially Fatal: Potentiates bone marrow suppression caused by anticancer drugs.  Diuretic-induced vol depletion can potentiate aminoglycoside nephrotoxicity.  Impairs action of Oral   hypoglycaemic agents.  Enhancesdigitalis toxicity due to hypokalaemia.  vol depletion enhances lithium toxicity, conversely, sudden withdrawal of diuretics may result in subtherapeutic levels of circulating lithium.  Prolonged paralysis with tubocurarine due to hypokalaemia.

Pregnancy Category (US FDA)

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect that was not confirmed in controlled studies in women in the 1sttrimester.
 

 Category D: If used in gestational HTN. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk.

Storage

Oral:  Store at 15-30°C.

Mechanism of Action

Chlorthalidone is an Oral , long acting antihypertensive/diuretic.  It is a monosulfamyl diuretic that acts by enhancing the excretion of sodium and chloride ions, and water by interfering with the transport of sodium ions across the renal tubular epithelium.  Their primary site of action appears to be at the cortical diluting segment in the nephron of the loop of Henle. Onset: 2 hr. Duration: 48-72 hr.  Absorption: Erratic absorption from the GI tract.  Distribution: Binds to red blood cells; crosses the placenta and enters breast milk.  Protein-binding: Weak.  Excretion: Urine; 40-60 hr.

mph Class

Diuretics

ATC Classification

C03BA04 - chlorthalidone; Belongs to the class of low-ceiling sulfonamide diuretics.

 

Search Google: Chlorthalidone

Brand/Product Info


Total Products : 1 
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
THALIDON Popular Pharmaceuticals Ltd. Chlorthalidone USP 25mg Tablet 30's: 150.60 MRP

Gen. MedInfo

Why is this medication prescribed?

Chlorthalidone, a 'water pill,' is used to treat high blood pressure and fluid retention caused by various conditions, including heart disease.  It causes the kidneys to get rid of unneeded water and salt from the body into the urine.

This medicine is sometimes prescribed for other uses; ask your Doctor for more information.

How should this medicine be used?

Chlorthalidone comes as a tablet to take by mouth.  It usually is taken once a day or every other day after a meal, preferably breakfast.  It is best to take this medicine in the morning to avoid going to the bathroom during the night.  Follow the directions on your prescription label carefully, and ask your Doctor to explain any part you do not understand.  Take chlorthalidone exactly as directed.  Do not take more or less of it or take it more often than prescribed by your doctor.

Chlorthalidone controls high blood pressure but does not cure it.  Continue to take chlorthalidone even if you feel well.  Do not stop taking chlorthalidone without talking to your doctor.

Other uses for this medicine

Chlorthalidone may also be used to treat patients with diabetes insipidus and certain electrolyte disturbances and to prevent kidney stones in patients with high levels of calcium in their blood.  Talk to your doctor about the possible risks of using this medicine for your condition.

What Special Precautions should I follow?

Before taking chlorthalidone,

  • tell your Doctor if you are allergic to chlorthalidone, sulfa drugs, or any other drugs.
  • tell your Doctor what prescription and nonprescription medications you are taking, especially other medicines for high blood pressure, anti-inflammatory medications such as ibuprofen or naproxen, corticosteroids, lithium, medications for diabetes, probenecid, and vitamins.  If you also are taking cholestyramine or colestipol, take it at least 1 hour after chlorthalidone.
  • tell your doctor if you have or have ever had diabetes, gout, or kidney, liver, thyroid, or parathyroid disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.  If you become pregnant while taking chlorthalidone, consult your doctor immediately.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking chlorthalidone.
  • you should know that this drug may make you drowsy.  Do not drive a car or operate machinery until you know how this drug affects you.
  • remember that alcohol can add to the drowsiness caused by this drug.
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen.  Chlorthalidone may make your skin sensitive to sunlight.

What special dietary instructions should I follow?

Follow your doctor's directions.  They may include following a daily exercise program or a low-salt or low-sodium diet, potassium supplements, and increased amounts of potassium-rich foods in your diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it.  However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule.  Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Frequent urination should go away after you take chlorthalidone for a few weeks.

Tell your doctor if any of these symptoms are severe or do not go away:

  • muscle weakness
  • dizziness
  • cramps
  • thirst
  • stomach pain
  • upset stomach
  • vomiting
  • diarrhea
  • loss of appetite
  • headache
  • hair loss
  • sore throat with fever
  • unusual bleeding or bruising
  • severe skin rash with peeling skin
  • difficulty breathing or swallowing

If you experience any of the following symptoms, consult your doctor immediately:

If you experience a serious side effect, you or your doctor may send a report to the Office of Directorate General, Drugs Administration.

What Storage conditions are needed for this medicine?

Keep this medicine in the container it came in, tightly closed, and out of reach of children.  Store it at room temperature and away from excess heat and moisture.  Throw away any medicine that is outdated or no longer needed.  Talk to your Doctor about the proper disposal of your medicine.

In case of emergency/overdose

In case of overdose, consult your Doctor.  If the victim has collapsed or is not breathing, consult local medical emergency services.

 

 

 

 

Before Calling Emergency

Determine the following information:

  • Patient's age, weight and condition
  • Name of the product/medicine (ingredients and strengths, if possible)
  • Time it was swallowed/taken
  • Amount swallowed/taken

 What to Expect at the Emergency Room

 The Health Care Provider/ Emergency Doctor will measure and monitor the patient's vital signs, including temperature, pulse, breathing rate and blood pressure. Symptoms will be treated as appropriate. The patient may receive:

  • Antidote, gastric lavage, activated charcoal or other drugs/procedures as required
  • Blood tests to determine body chemical levels and blood acid/base balance
  • EKG/ECG test
  • Medicines to correct fluid and electrolyte imbalances

Do not let anyone else take your medicine.  

It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals or other dietary supplements.  You should bring this list with you each time you visit a doctor or if you are admitted into a hospital.  It is also important information to carry with you in case of emergencies.