mph Bangladesh


Amlodipine + Atenolol

PCI - Contraindicated in pregnancy

LCaution when used during lactation - Caution when used during lactation

Molecule Info

 
Indication(s) & dosage Chronic stable angina, Hypertension
Adult: Per tablet contains atenolol 25 or 50 mg and amlodipine (as besylate) 5 mg: 1 tab once daily, may increase to 2 tablets daily if needed. 
Elderly: Per tablet contains atenolol 25 mg and amlodipine (besylate) 5 mg: Initiate with 1 tablet daily. 
Renal impairment: Per tablet contains atenolol 25 mg and amlodipine (besylate) 5 mg: Initiate with 1 tablet daily.
Administration May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take with antacids, Fe or dairy products.
Overdose Overdosage may cause hypotension and less commonly, congestive cardiac failure. Unabsorbed drug may be removed by gastric lavage or use of activated charcoal. Symptomatic treatment may be administered.
Contraindications Hypotension, sinus bradycardia, 2nd & 3rd degrees of heart block, cardiogenic shock, overt congestive failure, poor LV function, hypersensitivity to either component, pregnancy.
Special Precautions Excessive fall of BP may occur in elderly patients. Caution in patients with COPD, thyrotoxicosis, congestive failure, vasospastic angina, hepatic & renal impairment. Caution in diabetic patients as beta-blockers may mask tachycardia occurring with hypoglycaemia. Withdrawal should be gradual. Lactation. Safety and efficacy have not been established in children. Not to be used in untreated phaeochromocytoma.
Adverse Drug Reaction(s) Headache, hypotension, dizziness, breathlessness, fatigue, muscle cramps, bradycardia, palpitations, flushing, oedema, dyspnoea, dyspepsia, cold extremities. Drowsiness, chestpain & impotence rarely. Hypersensitivity reactions.
Drug Interactions Additive effect when used with catecholamine depleting drugs; monitor for hypotension and/or marked bradycardia. If used with clonidine, clonidine withdrawal should occur a few days after withdrawal of the beta-blocker to prevent rebound hypertension; if replacing clonidine by beta-blocker, beta-blocker should be introduced only after clonidine administration has stopped for several days. Concurrent use with prostaglandin synthase inhibiting drugs (e.g. indomethacin) may reduce the hypotensive effects of beta-blockers.
Pharmacology Atenolol is a cardioselective beta blocker. Amlodipine is a dihydropyridine calcium-channel blocker that blocks the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Combination of the two drugs results in additive antihypertensive action.
Absorption: Amlodipine: Plasma levels peak 6-12 hr after oral admin; absolute bioavailability is estimated to be 64-90%. Atenolol: Absorption is rapid and consistent but incomplete; about 50% of an oral dose is absorbed in the GI tract; plasma levels peak 2-4 hr after oral admin.
Distribution: Amlodipine: 93% bound to plasma proteins. Atenolol: 6-16% bound to plasma proteins.
Metabolism: Amlodipine: About 90% converted to inactive metabolites hepatically. Atenolol: Little or no hepatic metabolism.
Excretion: Amlodipine: 10% of parent compound and 60% of the metabolites are removed in the urine; elimination from the plasma is biphasic with terminal half-life of about 30-50 hr. Atenolol: 50% of the oral dose is removed unchanged in the faeces; absorbed drug is removed mainly via renal elimination; half-life is about 6-7 hr.
ATC Classification C07AB03 - atenolol; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases. 
C08CA01 - amlodipine; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Brand/Product Info


Total Products : 59                                                           
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ALOTEN Kemiko Pharmaceuticals Ltd Amlodipine 5mg+ Atenolol BP 25mg Tablet 50's: 212.50 MRP
ALOTEN Forte Kemiko Pharmaceuticals Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 50's: 225.00 MRP
AMDIN Plus Alco Pharma Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 50's: 225.00 MRP
AMDOCAL PLUS 25 Beximco Pharmaceuticals Ltd Amlodipine 5mg+ Atenolol BP 25mg Tablet 30's: 157.50 MRP
AMDOCAL PLUS 50 Beximco Pharmaceuticals Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 60's: 360.00 MRP
AMICARD Plus Aexim Pharmaceutical Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 50's: 150.00 MRP
AMLOBET Sun Pharmaceutical (Bangladesh) Ltd. Amlodipine 5mg+ Atenolol BP 25mg Tablet 50's: 227.50 MRP
AMLOCARD Plus-25 Drug International Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 50's: 225.00 MRP
AMLOCARD Plus-50 Drug International Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 50's: 250.00 MRP
AMLOCOM Beacon Pharmaceuticals Limited Amlodipine 5mg+ Atenolol BP 25mg Tablet 50's: 225.50 MRP
AMLOSIN Plus Doctors Chemical Works Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 120.00 MRP
AMLOTEN 25 The Acme Laboratories Ltd. Amlodipine 5mg+ Atenolol BP 25mg Tablet 30's: 128.10 MRP
AMLOTEN 50 The Acme Laboratories Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 135.60 MRP
AMLOVAS AT Popular Pharmaceuticals Ltd. Amlodipine 5mg+ Atenolol BP 25mg Tablet 50's: 201.03 MRP
AMOCAL-AT Opsonin Pharma Limited Amlodipine 5mg+ Atenolol BP 25mg Tablet 30's: 135.00 MRP
AMOCAL-AT 5/25 Opsonin Pharma Limited Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 128.10 MRP
AMPIL Plus The White Horse Pharma Amlodipine 5mg+ Atenolol BP 50mg Tablet 50's: 225.00 MRP
AMPRE-PIus Modern Pharmaceuticals Ltd Atenolol 50mg & amlodipine 5mg/tablet Tablet 50s pack: 120.00 MRP
AMPRE-Plus Kumudini Pharma Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 120.00 MRP
AMTINOL Plus Euro Pharma Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 135.00 MRP
ANGICAL-50 Apex Pharmaceuticals Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 135.00 MRP
ATEPINE Pharmadesh Laboratories Limited Amlodipine 5mg+ Atenolol BP 25mg Tablet 30's: 135.00 MRP
ATEZEN Plus Zenith Pharmaceuticals Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 50's: 180.00 MRP
BETACAL Orion Pharma Ltd. Amlodipine 5mg+ Atenolol BP 25mg Tablet 50's: 226.00 MRP
BETANOL-A 25 Sanofi Amlodipine 5mg+ Atenolol BP 25mg Tablet 50's: 213.50 MRP
BETANOL-A 50 Sanofi Amlodipine 5mg+ Atenolol BP 50mg Tablet 50's: 226.00 MRP
BPNOL-Plus Delta Pharma Limited Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 120.00 MRP
CALBETA Unimed & Unihealth Manufacturers Ltd. Amlodipine 5mg+ Atenolol BP 25mg Tablet 30's: 135.00 MRP
CALCHEK Plus General Pharmaceuticals Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 135.60 MRP
CALOCK Plus 25 Medimet Pharmaceuticals Ltd Amlodipine 5mg+ Atenolol BP 25mg Tablet 42's: 168.00 MRP
CALOCK Plus 50 Medimet Pharmaceuticals Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 42's: 189.00 MRP
CALPIN Plus 25 Globe Pharmaceuticals Ltd Atenolol 25mg & amlodipine 5mg/tablet Tablet 30s pack: 120.00 MRP
CALPIN Plus 50 Globe Pharmaceuticals Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 135.00 MRP
CAMLODIN PLUS 5/25 Square Pharmaceuticals Ltd. Amlodipine + Atenolol (5mg + 25mg) Tablet 3x10's: 150.60 MRP
CAMLODIN PLUS 5/50 Square Pharmaceuticals Ltd. Amlodipine + Atenolol (5mg + 50mg) Tablet 5x10's: 301.00 MRP
CARDIPIN Plus Renata Limited Amlodipine 5mg+ Atenolol BP 50mg Tablet 50's: 226.00 MRP
CARDOSIA Plus Pharmasia Limited Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 135.60 MRP
COMBICARD Healthcare Pharmacuticals Ltd. Atenolol 50mg & amlodipine 5mg/tablet Tablet 50s pack: 135.00 MRP
COMBICARD Healthcare Pharmacuticals Ltd. Amlodipine Besilate BP equivalent to Amlodipine 5mg +Atenolol BP 50mg Tablet 30's MRP 180 Tk
CV NOR-A Navana Pharmaceuticals Limited Amlodipine 5mg+ Atenolol BP 25mg Tablet 30's: 135.60 MRP
DIPICARD-25 Peoples Pharma Ltd. Amlodipine 5mg+ Atenolol BP 25mg Tablet 50's: 175.00 MRP
DIPLOR Plus-25 IBN SINA Pharmaceutical Industry Ltd. Amlodipine 5mg+ Atenolol BP 25mg Tablet 30's: 120.00 IP
DIPLOR Plus-50 IBN SINA Pharmaceutical Industry Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 150.00 IP
EMLON Plus Biopharma Laboratories Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 135.60 MRP
Fixocard 25 Incepta Pharmaceuticals Limited Amlodipine Besilate BP equivalent to Amlodipine 5mg +Atenolol BP 25mg Tablet 10x5's:MRP 262.5 Tk
Fixocard 50 Incepta Pharmaceuticals Limited Amlodipine Besilate BP equivalent to Amlodipine 5mg +Atenolol BP 50mg Tablet 10x5's:MRP 300 Tk
HIPRE Plus Pacific Pharmaceuticals Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 150.00 MRP
LOCARD Plus Jayson Pharmaceuticals Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 90.60 IP
LODICARD Aristopharma Ltd. Amlodipine 5mg+ Atenolol BP 25mg Tablet 50's: 230.00 MRP
LOPIN Plus Edruc Limited Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 135.00 IP
PRISTIN-OL Novo Healthcare and Pharma Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 120.00 MRP
SIDOPLUS 25 Eskayef Bangladesh Ltd Amlodipine 5mg+ Atenolol BP 25mg Tablet 40's MRP: 170.00
SIDOPLUS 50 Eskayef Bangladesh Ltd Amlodipine 5mg+ Atenolol BP 50mg Tablet 40's MRP: 180.00
TENOCAB 25 ACI Ltd. Amlodipine 5mg+ Atenolol BP 25mg Tablet 50's: 201.00 MRP
TENOCAB 50 ACI Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 50's: 226.00 MRP
TENOPIN Sharif Pharmaceuticals Ltd. Amlodipine 5mg+ Atenolol BP 25mg Tablet 30's: 135.00 MRP
VASOPIN 50 Silva Pharmaceuticals Limited Atenolol 50mg & amlodipine 5mg/tablet Tablet 50s pack: 120.00 MRP
VASOPIN Plus Silva Pharmaceuticals Limited Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 135.51 MRP
VESOCAL Plus Rangs Pharmaceuticals Ltd. Amlodipine 5mg+ Atenolol BP 50mg Tablet 30's: 135.00 MRP

Gen. MedInfo

Why this drug is prescribed:

This combination of drug is used for treatment of hypertension and stable angina. This combination product is generally used because of their additive effects that can help to alleviate the condition more effectively.

Precaution:

Excessive low blood pressure may occur in elderly patients. Caution should be taken in patients with thyrotoxicosis, congestive failure, vasospastic angina, hepatic & renal impairment. Drug withdrawal should be done gradually.

Consult your Doctor for further discussing the side effects. May require hospitalization in case of emergency.

Side effects:

Immune system disorders: Allergic reaction

Nervous system disorders: Headache, Drowsiness, Syncope, Abnormal skin sensations, Peripheral neuropathy

Cardiac disorders: Palpitations, Low heart rate

Respiratory disorders: Breathlessness Dyspnoea

Gastrointestinal disorders: Abdominal pain, Vomiting, Stomach upset, Gastritis

Musculoskeletal and bone disorders: Muscle and joint pain, Muscle cramps, Back pain

Others: Chest pain, Oedema, Fatigue, Flushing, Cold extremities, Impotence

Simple Breath Test Might Diagnose Heart Failure An experimental breath test, designed to quickly identify patients suffering from heart failure simply by analyzing the contents of a...
Osteoporosis drug stops Breast cancer growth   News & Events News & Events     HIGHLIGHTS Osteoporosis drug stops growth of breast cancer...
Generic drug safety info loophole FDA plans to close generic drug safety info loophole The US Food and Drug Administration has announced plans to speed up the dissemination of...
Large trials unpublished   News & Events News & Events   HIGHLIGHTS Almost 1 in 3 of large clinical trials unpublished after...
TB activists boo Indian minister News & Events News & Events   HIGHLIGHTS TB activists at world conference boo Indian minister off...
Key bone marrow protein identified News & Events News & Events   HIGHLIGHTS Key bone marrow protein identified as potential new leukemia...