Atenolol

(a ten' oh lole)

PContraindicated In Pregnancy - Contraindicated in pregnancy

LCaution when used during lactation - Caution when used during lactation

Molecule Info

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Indication(s) & Dosage Hypertension
Adult: 25-100 mg daily as a single dose, depending on response. Takes 1-2 wk for full effect to be observed.
CrCl (ml/min) Dosage Recommendation
15-35 50 mg daily.
<15 25 mg daily or 50 mg on alternate days.
Dialysis 25-50 mg after each dialysis.

Angina Pectoris
Adult: 50-100 mg orally daily given as single or divided doses. Max dose: 200 mg daily.
CrCl (ml/min) Dosage Recommendation
15-35 50 mg daily.
<15 25 mg daily or 50 mg on alternate days.
Dialysis 25-50 mg after each dialysis.

Prophylaxis of migraine
Adult: 50-100 mg orally daily.
CrCl (ml/min) Dosage Recommendation
15-35 50 mg daily.
<15 25 mg daily or 50 mg on alternate days.
Dialysis 25-50 mg after each dialysis.

Intravenous
Emergency treatment of cardiac arrhythmias
Adult: 2.5 mg injected at a rate of 1 mg/minute, may repeat every 5 minutes if needed. Max: 10 mg. Alternatively, 150 mcg/kg to be infused over 20 minutes. May repeat Inj or infusion procedure every 12 hr as needed. Once control is achieved, maintain with oral doses of 50-100 mg/day.
CrCl (ml/min) Dosage Recommendation
15-35 10 mg once every 2 days.
<15 10 mg once every 4 days.

Intravenous
Acute myocardial infarction
Adult: To be given within 12 hr of the onset of chest pain. Inject 5-10 mg slowly at a rate of 1 mg/minute, followed by an oral dose of 50 mg 15 minutes later (if no adverse effects result from the inj). Alternatively, repeat an IV dose of 5 mg 10 minutes after the initial doser followed by an oral dose of 50 mg 10 minutes after the last IV dose. A further oral dose of 50 mg may be given 12 hr later. Thereafter, maintain with 50 mg every 12 hr or 100 mg/day for 6-9 days post-MI.
CrCl (ml/min) Dosage Recommendation
15-35 10 mg once every 2 days.
<15 10 mg once every 4 days.

Special Populations: Renal impairment: CrCl: 15-35 mL/min: 50 mg daily by mouth or 10 mg once every 2 days IV; <15 mL/min: 25 mg daily by mouth or 10 mg once every 4 days IV.

Administration May be taken with or without food.
Overdosage Symptoms include lethargy, sinus pause, bradycardia, hypotension, bronchospasm and/or hypoglycaemia. Unabsorbed drug may be removed by induced emesis, gastric lavage or admin of activated charcoal.
Contraindications Hypersensitivity. Sinus bradycardia, sinus node dysfunction, heart block >1stdegree, compensated cardiac failure, cardiogenic shock, bronchospastic diseases, peripheral vascular diseases. Pregnancy.
Special Precautions Compensated heart failure. Variant angina, acute MI, DM; peripheral vascular disorders; hepatic and renal dysfunction; elderly patients, children. Lactation. If atenolol and clonidine are co-admin, then gradual withdrawal of clonidine should take place a few days after withdrawal of atenolol.
Adverse Drug Reaction(s) Bronchospasm; cold extremities, fatigue, dizziness, insomnia, lethargy, confusion, headache, depression, nightmares, nausea, diarrhoea, constipation, impotence and paraesthesia.
Potentially Fatal: Heart failure, 2nd or 3rd degree AV block.
Drug Interactions Decreased effect with aluminum and calcium salts, barbiturates, cholestyramine, NSAIDs, ampicillin, rifampicin.
Potentially Fatal: May increase effects of drugs which slow AV conduction (digoxin, verapamil, diltiazem).
Lab Interference Increased glucose levels, decreased HDL.
Pregnancy Category (FDA) Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Storage Intravenous: Store at 20-25°C. Oral: Store at 20-25°C.
Pharmacology Atenolol is a competitive cardioselective β1-blocker. It does not have effect on β2-receptors except in high doses. Its cardioselectivity is dose-related. Atenolol reduces resting and exercise-induced heart rate as well as myocardial contractility. Peripheral β-blockade may result in vasoconstriction. Atenolol reduces BP and heart rate which results in reduced myocardial work and O2 requirement leading to improved exercise tolerance and reduced frequency and intensity of anginal attack.
Absorption: Incompletely absorbed from the GI tract (oral); peak plasma concentrations after 1-4 hr.
Distribution: Low lipid solubility, blood-brain barrier (small amounts); crosses the placenta and enters breast milk (concentrations higher than those in plasma). Protein-binding: Minimal.
Metabolism: Hepatic: Minimal.
Excretion: Via urine; elimination half-life: 6-7 hr.
ATC Classification C07AB03 - atenolol; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.

 

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Brand/Product Info

 

Total Products : 30                              
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ANETOL Ambee Pharmaceuticals Ltd. Atenolol 50mg Tablet 50mg x 100's: 80.00 MRP
ANOL Modern Pharmaceuticals Ltd Atenolol 50mg Tablet 50mg x 100's: 77.00 MRP
ANOL-50 Medicon Laboratories Ltd Atenolol 50mg Tablet 50mg x 100's: 76.00 MRP
ANOLOL Euro Pharma Ltd. Atenolol 50mg, 100mg Tablet 100's each: 77.00 & 138.00 MRP
ATENOL Pharmadesh Laboratories Limited Atenolol 50mg/tablet Tablet 50mg x 100s pack: 80.00 MRP
ATEZEN Zenith Pharmaceuticals Ltd. Atenolol 50mg Tablet 100's each: 77.00 & 136.00 MRP
ATIN Jayson Pharmaceuticals Ltd. Atenolol 50mg Tablet 50mg x 100's: 76.00 MRP
ATOL Mystic Pharmaceuticals Limited Atenolol 50mg Tablet 50mg x 100's: 75.00 MRP
B-CARD-50 Nipa Pharmaceuticals Ltd. Atenolol 50mg Tablet 50mg x 100's: 70.00 MRP
BETANOL Sanofi Atenolol 25mg, 50mg, 100mg Tablet 25mg x 200's, 50mg x 200's, 100mg x 100's: 90.44, 154.28 & 136.99 MRP
BETASEC Opsonin Pharma Limited Atenolol 50mg Tablet 50mg x 100's: 76.00 MRP
BPNOL Delta Pharma Limited Atenolol 50mg Tablet 50mg x 100's: 76.06 MRP
CARDILOCK Alco Pharma Ltd Atenolol 50mg Tablet 50mg x 100's: 77.00 MRP
CARDIPRO Square Pharmaceuticals Ltd. Atenolol 50mg Tablet 10x10's: 77.00 MRP
CARDISEF Supreme Pharmaceuticals Ltd. Atenolol 50mg, 100mg Tablet 100'seach: 77.00 & 136.00 MRP
CARSEC Medimet Pharmaceuticals Ltd Atenolol 50mg, 100mg Tablet 140's each: 105.00 & 189.00 MRP
ENOL Edruc Limited Atenolol 50mg Tablet 100's: 77.00 IP
ETNOL Biopharma Laboratories Ltd Atenolol 50mg, 100mg Tablet 100's each: 77.00 & 138.00 MRP
LONET Beximco Pharmaceuticals Ltd Atenolol BP 50 & 100mg Film Coated Tablet 100's each: 77.00 & 137.00 MRP
LONET 50 Beximco Pharmaceuticals Ltd Atenolol BP 50mg Film Coated Tablet 100's: 77.00 MRP
LOPRES Orion Pharma Ltd. Atenolol 50mg Tablet 50mg x 100's: 70.00 MRP
NORMATEN Navana Pharmaceuticals Limited Atenolol 50mg Tablet 50mg x 100's: 76.00 MRP
NORPRESS Kemiko Pharmaceuticals Ltd Atenolol 50mg, 100mg Tablet 50mg x 100's, 100mg x 60's: 75.00 & 75.00 MRP
PRECINOL Doctors Chemical Works Ltd Atenolol 50mg Tablet 50mg x 100's: 73.00 MRP
RECARD Rephco Laboratories Ltd. Atenolol 50mg & 100mg/tablet Tablet 50mg x 100s pack: 75.00 MRP
TENOCARD Aristopharma Ltd. Atenolol 50mg Tablet 50mg x 100's: 75.00 MRP
TENOL Sonear Laboratories Ltd. Atenolol 50mg/tablet Tablet 50mg x 100s pack: 75.00 MRP
TENOLOC The Acme Laboratories Ltd. Atenolol 50mg, 100mg Tablet 100's each: 77.00 & 137.00 MRP
TENOMIN Pacific Pharmaceuticals Ltd. Atenolol 50mg Tablet 50mg x 100's: 77.00 MRP
TENOREN ACI Ltd. Atenolol 25mg, 50mg, 100mg Tablet 25mg x 50's, 50mg x 150's, 100mg x 100's: 22.50, 115.50 & 138.00 MRP

 

Gen. MedInfo

Why this medicine is required?

Atenolol helps to keep your blood pressure under control. It may also be used to treat certain heart diseases such as angina pectoris (chest pain) and arrhythmia (irregular heart beats). Atenolol is also used to reduce the risk of heart complications after a heart attack.

Atenolol may also be used to relieve palpitations (fast and irregular heartbeats) commonly experienced by people with an overactive thyroid gland.

How to take this medicine?

Take Atenolol exactly as directed by your doctor. Do not take more or less than instructed by your doctor.

Atenolol must be taken regularly for it to work well. Continue taking Atenolol even when you feel better. Do not stop taking it unless instructed by your doctor.

Atenolol may be taken with or without food. Try to take it at the same time each day.

Missing Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

Remember to take your medicine regularly. Atenolol must be taken exactly as directed for it to be effective. If you often forget to take your medicine, let your doctor and pharmacist know.

When not to use this medicine?

Atenolol may not be suitable for certain heart conditions. Alert your doctor if you suffer from any heart conditions.

Before taking this medicine

Alert your doctor if you have kidney or thyroid disease, asthma, diabetes, any disease that affects your blood vessels or blood circulation as well as other illnesses such as myasthenia gravis and phaeochromocytoma. You should also inform your doctor if you are seeing a psychiatrist.

Alert your doctor if you are pregnant or breastfeeding. Do not breastfeed while you are being treated with Atenolol.

You may experience dizziness when getting up from a sitting or lying position, especially if you are taking Atenolol for the very first time. This is common and should improve gradually as you get used to the medicine. It will help if you get up slowly from a sitting or lying position. If you feel dizzy, do not drive or take part in any activity in which you need to be alert.

If you also have diabetes, monitor your blood sugar more closely.

If you are going for an operation, including minor operations and dental work, always inform your doctor, surgeon or dentist that you are taking Atenolol.

Why is it important to keep my appointments with the doctor?
Your blood pressure may rise to unsafe levels without you noticing it. Your doctor needs to monitor your condition and check your response to the medication regularly.

What lifestyle changes can I make to improve my blood pressure?

Regular exercise will help lower your blood pressure and improve your overall health. Speak to your doctor about what type of exercise would be suitable for you. If you have not exercised for a long time, start with light exercises such as slow walks. Regular exercise will also help you to maintain a healthy weight and this is important in helping you control your blood pressure.

If you smoke, you should try to quit. Smoking is harmful to your blood pressure, heart and overall health. Speak to your doctor or pharmacist about ways to kick your smoking habit.

Try to keep stress levels under control as stress will cause your blood pressure to go up.

What side effects could happen?

Atenolol may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be alert.

Atenolol may also cause tiredness, diarrhoea, nausea, difficulty sleeping, numbness or tingling of the fingers and toes. Alert your doctor if these side effects are severe or refuse to go away.

Other side effects are less common but may need medical attention. If you experience wheezing, difficulty breathing, abnormally slow heart rate or rashes, alert your doctor.

Taking this with other medicines.

Alert your doctor if you are taking any other medicines, especially those listed here:

- other medicines for high blood pressure or heart disease, especially clonidine, prazosin
- migraine medicines such as ergotamine

Do not take antacids together with Atenolol. Antacids may affect the effectiveness of Atenolol. If you must take antacids, take it at least 1 hour before or 2 hours after you take Atenolol.

Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

Restrictions on the type of food I can take.

Avoid alcohol.

How should I store?

Store in a cool, dry place away from the reach of children. Medicines must be used within expiry date.

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