PCI  : Contraindicated in pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

| See TERMINOLOGY & ABBREVIATIONS |

Indication(s) & Dosage

Hypertension
Adult: 2.5-10 mg daily as a single dose. Max: 20 mg daily. 
Hepatic impairment: Severe impairment: Initially, 2.5 mg daily. Max: 10 mg daily. 

Angina pectoris
Adult: 2.5-10 mg daily as a single dose. Max: 20 mg daily. 
Hepatic impairment: Severe impairment: Initially, 2.5 mg daily. Max: 10 mg daily. 

Heart failure
Adult: Initially, 1.25 mg once daily doubled after 1 wk if tolerated, then increased gradually at 1-4-wk intervals. Max: 10 mg daily. 
Renal impairment: Dosage reduction may be necessary. 
Hepatic impairment: Dosage reduction may be necessary.

Special Populations: Management of HTN and angina pectoris in severe renal impairment (CrCl <20 mL/min) and severe hepatic impairment: Max dose: 10 mg daily.

Administration May be taken with or without food.
Overdosage Symptoms include bradycardia, hypotension, congestive heart failure, bronchospasm, and hypoglycemia. Treatment include stopping the drug and instituting supportive and symptomatic measures.
Contraindications Low cardiac output and uncompensated cardiac failure; sinus bradycardia, 1st° heart block, cardiogenic shock, bronchospasm; severe haemorrhage. Pregnancy.
Special Precautions Bronchospastic disease, hyperthyroidism, peripheral vascular disease, undergoing anaesthesia. Monitor blood glucose regularly. May mask symptoms of hypoglycaemia. Elderly. Gradual withdrawal is advised. Lactation.
Adverse Drug Reaction(s) Giddiness, headache, fatigue, bradycardia. Nausea, vomiting, diarrhoea or constipation, stomach discomfort, mild ocular stinging, photophobia, keratitis, decreased sexual ability. GI disturbances, dyspnoea, cold extremities, insomnia, hallucination, drowsiness and mood alterations.
Potentially Fatal: AV block, bradycardia. Rare but may occur in patients with preexisting cardiac disease. Includes severe bronchospasm, hypoglycaemia, hypotension, orthostatic hypotension, bradyarrhythmias. 'Rebound phenomenon' leading to unstable angina or MI on sudden withdrawal.
Drug Interactions Decreased effect with aluminum and calcium salts, barbiturates, cholestyramine, NSAIDs, ampicillin, rifampicin. May mask tachycardia from hypoglycaemia induced by insulin and oral hypoglycaemics. Effects of other antihypertensives may be intensified.
Potentially Fatal: May increase the effects of drugs which slow AV conduction, α-blockers and α-adrenergic stimulants. Enhances the action of anaesthetic agents, clonidine, calcium antagonists, digitalis, hypoglycaemic agents and NSAIDs.

Lab Interference Increased cholesterol, thyroxine, glucose and triglycerides levels.
Pregnancy Category (FDA)

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Category D: in 2nd & 3rd trimesters. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Storage Store below 25°C.
Pharmacology Bisoprolol selectively and competitively blocks β-1 receptors but has little or no effect on β-2 receptors except at high doses.
Absorption: Absorbed completely from the GI tract (oral); peak plasma concentrations after 2-4 hr.
Distribution: Protein-binding: 30%.
Metabolism: In the liver.
Excretion: Excreted in urine. 10-12 hr (elimination half-life).
ATC Classification C07AB07 - bisoprolol; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.

 

Search Google: Bisoprolol 

Brand/Product Info


Total Products : 9         
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ANCOR Aristopharma Ltd. Bisoprolol hemifumarate 2.5, 5 & 10mg Tablet 2.5mg x 30's, 5mg x 30's, 10mg x 10's: 180.00, 300.00 & 160.00 MRP
B-PROLOL Sharif Pharmaceuticals Ltd. Bisoprolol hemifumarate 2.5 & 5mg Tablet 2.5mg x 30's, 5mg x 30's: 180.00 & 300.00 MRP
BISLOL Opsonin Pharma Limited Bisoprolol hemifumarate 2.5, 5 & 10mg Tablet 2.5mg x 30's, 5mg x 30's, 10mg x 30's: 180.00, 300.00 & 480.00 MRP
BISOLOC Orion Pharma Ltd. Bisoprolol hemifumarate 2.5 & 5mg Tablet 2.5mg x 30's, 5mg x 30's: 180.00 & 300.00 MRP
BISOPRO 2.5 Incepta Pharmaceuticals Limited Bisoprolol Fumarate USP 2.5 mg Tablet 30's: 180.00 MRP
BISOPRO 5 Incepta Pharmaceuticals Limited Bisoprolol Fumarate USP 5mg Tablet 30's: 300.00 MRP
CONBIS R A K Pharmaceuticals Pvt. Ltd. Bisoprolol hemifumarate 2.5 & 5mg Tablet 2.5mg x 30's, 5mg x 30's: 180.00 & 300.00 MRP
CONCOR Popular Pharmaceuticals Ltd. Bisoprolol hemifumarate 2.5, 5 & 10mg Tablet 2.5mg x 30's, 5mg x 30's, 10mg x 30's: 369.00, 492.30 & 780.00 MRP
TENOBIS Drug International Ltd Bisoprolol hemifumarate 2.5 & 5mg Tablet 2.5mg x 50's, 5mg x 30's: 300.00 MRP

Gen. MedInfo

Why do I need Bisoprolol?

Bisoprolol helps to keep your blood pressure under control. It may also be used to treat heart diseases
such as angina pectoris (chest pain) and heart failure.

How do I take Bisoprolol?

Take Bisoprolol exactly as directed by your doctor. Do not take more or less than instructed by your doctor. 
Bisoprolol must be taken regularly for it to work well. Continue taking Bisoprolol even when you feel better. Do not stop taking it unless instructed by your doctor.
Bisoprolol may be taken with or without food. Try to take it at the same time each day.

What to do if I have forgotten to take Bisoprolol?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal schedule.
DO NOT double a dose under any circumstances.
Remember to take your medicine regularly. Bisoprolol must be taken exactly as directed for it to be effective. If you often forget to take your medicine, let your doctor know.

When to not use Bisoprolol?

Bisoprolol may not be suitable for certain heart conditions. Inform your doctor if you suffer from any heart conditions.

What to take note of while taking Bisoprolol?

Inform your doctor if you have kidney, liver or thyroid disease, asthma, diabetes, any disease that affects your blood vessels or blood circulation as well as other illnesses such as myasthenia gravis and phaeochromocytoma. You should also inform your doctor if you are seeing a psychiatrist.
Inform your doctor if you are pregnant or breastfeeding. Do not breastfeed while you are being treated with Bisoprolol.
You may feel dizzy when getting up from a sitting or lying down position, especially if you are taking Bisoprolol for the very first time. This is common and tomprove gradually as you get used to the medicine. It will help if you get up slowly from a sitting or lying position. If you feel dizzy, do not drive or take part in any activity in which you need to be Inform.

If you also have diabetes, monitor your blood sugar more closely.

If you are going for an operation, including minor operations and dental work, always inform your doctor, surgeon or dentist that you are taking Bisoprolol.

Why is it important to keep my appointments with the doctor?
Your blood pressure may rise to unsafe levels without you noticing it. Your doctor needs to monitor your condition and check your response to the medication regularly.

What lifestyle changes can I make to improve my blood pressure?

Regular exercise will help lower your blood pressure and improve your overall health. Speak to your doctor about what type of exercise would be suitable for you. If you have not exercised for a long time, start with light exercises such as slow walks. Regular exercise will also help you to maintain a healthy weight and this is important in helping you control your blood pressure.

If you smoke, you should try to quit. Smoking is harmful to your blood pressure, heart and overall health. Speak to your doctor or pharmacist about ways to kick your smoking habit.

Try to keep stress levels under control as stress will cause your blood pressure to go up.

What side effects could I experience?

Bisoprolol may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be Inform. 

Bisoprolol may also cause tiredness, diarrhoea, nausea, difficulty sleeping, numbness or tingling of the fingers and toes. Inform your doctor if these side effects are severe or refuse to go away.

Other side effects are less common but may need medical attention. Inform your doctor if you experience wheezing, difficulty breathing, abnormally slow heart rate or rashes.

Can I take this with other medicines?

Inform your doctor if you are taking any other medicines, especially those listed here:

- other medicines for high blood pressure or heart disease, especially clonidine, prazosin
- migraine medicines such as ergotamine
- rifampicin (a TB medicine)

Do not take antacids together with Bisoprolol. Antacids may affect the effectiveness of Bisoprolol. If you must take antacids, take it at least 1 hour before or 2 hours after you take Bisoprolol.

Always inform your doctor if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

How to store Bisoprolol?

Store in a cool, dry place away from the reach of children.
Medicines must be used within the expiry date.