Labetalol

(la bet' a lole)

P  - Caution when used during pregnancy

L  - Caution when used during lactation

Molecule Info

Indication & Dosage

Oral
Hypertension
Adult: As hydrochloride: Initially, 100 mg bid; increase gradually according to patient's response to 200-400 mg bid. Max dose: 2.4 g daily in 2-4 divided doses.
Elderly: Initially, 50 mg bid.
Intravenous
Emergency treatment of hypertension
Adult: As hydrochloride: 50 mg injected slowly for at least 1 min; repeat at 5-min intervals as necessary, up to 200 mg. Monitor BP and the patient should remain supine during and 3 hr after the procedure. Alternatively, 2 mg/min infusion at concentrations of 1 mg/ml or 2 mg/3 ml of a suitable diluent.
Intravenous
Hypertension in pregnancy
Adult: As hydrochloride: Start infusion at a rate of 20 mg/hr, then doubled every 30 min until a favourable response is achieved or a dose of 160 mg/hr is reached.
Intravenous
Hypertension after myocardial infarction
Adult: As hydrochloride: Start infusion at a rate of 15 mg/hr, then increase gradually until a favourable response is obtained or a dose of 120 mg/hr is reached.
Intravenous
Hypotensive anaesthesia
Adult: As hydrochloride: Initially, 10-20 mg; increase at 5-10 mg increments if satisfactory hypotension is not achieved after 5 minutes. Administer higher initial doses if halothane anaesthesia is not used.

Administration

Should be taken with food. Take immediately after meals.

Contraindications

2nd and 3rd degree heart block, cardiogenic shock, obstructive airway disease e.g. bronchial asthma, uncompensated heart failure, severe bradycardia, sick sinus syndrome, Prinzmetal's angina, severe peripheral arterial disease.

Special Precautions

Phaeochromocytoma, compensated heart failure, nonallergic bronchospasm. Avoid abrupt withdrawal. DM. Hepatic impairment. Perform LFTs. Elderly. Pregnancy and lactation.

Adverse Drug Reactions

Orthostatic hypotension, dizziness, fatigue, vertigo, paraesthesia, headache, nasal stuffiness, dyspnoea, diarrhoea, abdominal pain, sexual dysfunction, dyspepsia, nausea, vomiting, scalp tingling, rash, increased transaminases, nightmares, worsening of intermittent claudication.
Potentially Fatal: Hepatic injury.

Drug Interactions

Increased bioavailability with cimetidine. Decreased bioavailability with glutethimide. Increased incidence of tremors with TCAs. Additive hypotensive effect with nitroglycerin.
Potentially Fatal: Increased risk of bradycardia with drugs that slows AV conduction. Synergistic hypotensive effect with halothane.
 labetalol Drug Interactions

Lab Interference

False-positive results in fluorimetric analysis of urinary catecholamines.

Pregnancy Category

Category C: Either studies in animals have revealed adverse effects on the foetus and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Storage

Intravenous: Store at 2-30°C . Oral: Store at 2-30°C .

Pharmacology

Labetalol competitively inhibits the adrenergic stimulation of β-receptors within the myocardium, bronchial and vascular smooth muscle, and α1-receptors within vascular smooth muscle. It also has some intrinsic β2-agonist and membrane-stabilising activity.
Absorption: Absorbed readily from the GIT; peak plasma concentrations after 1-2 hr. Bioavailability increased by food.
Distribution: Protein-binding: 50%. Crosses the blood-brain barrier, placenta and enters breast milk.
Metabolism: Extensive first-pass metabolism.
Excretion: Via urine; also via faeces. Elimination half-life: 8 hr, 5.5 hr .

mph Class

Beta-Blockers

ATC Classification

C07AG01 - labetalol; Belongs to the class of alpha and beta blocking agents. Used in the treatment of cardiovascular diseases.

Search Google: Labetalol

Brand/Product Info


Total Products : 4    
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
LABECARD Popular Pharmaceuticals Ltd. Labetalol Hydrochloride USP 100 & 200mg Tablet 30's each: 180.60 & 301.20 MRP
LABECARD IV Popular Pharmaceuticals Ltd. Labetalol Hydrochloride USP 50mg/10ml Injection 50mg/10ml amp: 100.38 MRP
LABETA 100 Beximco Pharmaceuticals Ltd Labetalol Hydrochloride USP 100mg Tablet 60's: 361.20 MRP
LABETA 200 Beximco Pharmaceuticals Ltd Labetatol Hydrochloride USP 200mg Tablet 30's: 301.20 MRP

Gen. MedInfo

IMPORTANT WARNING:

Do not stop taking labetalol without talking to your doctor first. If labetalol is stopped suddenly, it may cause chest pain or heart attack in some people.

Why is this medication prescribed?

Labetalol is used to treat high blood pressure. Labetalol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure.

How should this medicine be used?

Labetalol may come as a tablet to take by mouth. It usually is taken two or three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take labetalol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Labetalol controls high blood pressure but does not cure it. Continue to take labetalol even if you feel well. Do not stop taking labetalol without talking to your doctor.

Other uses for this medicine

Labetalol is also used sometimes to treat angina and to treat patients with tetanus. Talk to your doctor about the possible risks of using this drug for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking labetalol,

  • tell your doctor if you are allergic to labetalol or any other drugs.
  • tell your doctor what prescription and nonprescription medications you are taking, especially other medications for high blood pressure or heart disease; cimetidine; nitroglycerin; medications for asthma, headaches, allergies, colds, or pain; and vitamins.
  • tell your doctor if you have or have ever had heart, kidney, or liver disease; asthma or other lung disease; severe allergies; diabetes; or pheochromocytoma.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking labetalol, consult your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking labetalol.
  • you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
  • remember that alcohol can add to the drowsiness caused by this drug.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Labetalol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dizziness
  • tingling scalp or skin
  • lightheadedness
  • excessive tiredness
  • headache
  • upset stomach
  • stuffy nose

If you experience any of the following symptoms, consult your doctor immediately:

  • shortness of breath or wheezing
  • swelling of the feet and lower legs
  • sudden weight gain
  • chest pain

This medication may cause other side effects.  Consult your doctor if you have any unusual problems while taking this.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to this medicine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

 


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.