Meclizine (Meclozine) + Pyridoxine

PCaution when 

used during lactation  - Caution when used during pregnancy

Molecule Info

 
Indication & Dosage

Management of nausea and vomiting (including Pregnancy-associated condition), dizziness associated with motion sickness, Management of vertigo associated with diseases affecting the vestibular system.

Adult: 25 to 100 mg daily, in divided dosage, depending upon clinical response. Motion Sickness : Initial dose of 25 to 50 mg should be taken one hour prior to embarkation for protection against motion sickness. The dose may be repeated every 24 hours for the duration of the journey.

Special Precautions Prostate hypertrophy, obstruction of bladder neck, narrow angle glaucoma, pyloric stenosis. May impair ability to drive or operate machinery. Pregnancy.
Adverse Drug Reactions Drowsiness, thickening of bronchial secretions, dry mouth, fatigue, blurred vision.
Drug Interactions Meclozine: Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol. Please consult detailed drug interactions before prescribing.
Lab Interference Pyridoxine: May cause false-positive results for urobilinogen in the spot test using Ehrlich's reagent.
Storage Oral: Store below 25°C.
Use in pregnancy/lactation & other population

Use in pregnancy and lactation
Pregnancy Category B. Reproduction studies in rats have shown cleft palates at 25-50 times the human dose. Epidemiological studies in pregnant women, however, donot
indicate that meclizine increases the risk of abnormalities when administered during pregnancy. Despite the animal findings, it would appear that the possibility of fetal harm
is remote. 
Usage in Children
Clinical studies establishing safety and effectiveness in children have not been done; therefore,usage is not recommended in children under 12 years of age.

Pharmacology Meclizine/Meclozine hydrochloride, a piperazine derivative, is a sedating antihistamine with antimuscarinic properties. It is mainly used in the prevention and treatment of nausea and vomiting associated with a variety of conditions.
Onset: Meclozine: 1 hr
Duration: Meclozine: 8-24 hr
Absorption: Pyridoxine: Readily absorbed from GI tract except in malabsorption syndromes or following gastric resection.
Metabolism: Pyridoxine: Converted to pyridoxal phosphate and pyridoxamine phosphate in the liver; riboflavin needed for further conversion of pyridoxine phosphate to pyridoxal phosphate which are the principal forms of the vitamin in the blood. Pyridoxal is further oxidised to 4-pyridoxic acid in liver.
Excretion: Meclozine: Plasma half-life: 6 hr. Pyridoxine: Excreted in urine (4-pyridoxic acid).
ATC Classification R06AE05 - meclizine/meclozine; Belongs to the class of piperazine derivatives used as systemic antihistamines.

Brand/Product Info


Total Products : 21                     
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
ACLIZ Plus Aristopharma Ltd. Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 100's: 300.00 MRP
ANCLIZ Monico Pharma Limited Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.00 MRP
ANOSEA Plus IBN SINA Pharmaceutical Industry Ltd. Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.00 IP
ANTINOS Pharmasia Limited Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.50 MRP
AVONEX Novo Healthcare and Pharma Ltd. Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 30's: 75.00 MRP
DEVOMIT Silva Pharmaceuticals Limited Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.57 MRP
EMEGO Plus Opsonin Pharma Limited Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.00 MRP
Emenil Plus Incepta Pharmaceuticals Limited Meclizine Hydrochloride USP 25 mg and Pyridoxine Hydrochloride BP 50 mg Film Coated Tablet 10x10's:MRP 300 Tk
EMEZIN Plus Eskayef Bangladesh Ltd Meclizine Hydrochloride USP 25mg+ Pyridoxine Hydrochloride BP 50mg Film Coated Tablet 50's MRP: 150.00
MACLIXINE General Pharmaceuticals Ltd Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.50 MRP
MEC-P Navana Pharmaceuticals Limited Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.50 MRP
MECPY Medicon Laboratories Ltd Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.00 MRP
NOMESIS TAB Healthcare Pharmacuticals Ltd. Meclizine Hydrochloride USP 25mg + Pyridoxine Hydrochloride BP 50mg Tablet 50's MRP 175 Tk
NVP The Acme Laboratories Ltd. Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.00 MRP
OPTIMIN Cosmic Chemical Industries Limited Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.00 MRP
PYRIMAC ACI Ltd. Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.50 MRP
S-VOM Sharif Pharmaceuticals Ltd. Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.00 MRP
V-NIL Alco Pharma Ltd Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.00 MRP
VERTINA PLUS Square Pharmaceuticals Ltd. Meclizine HCl 25mg + Pyridoxine HCl 50mg Tablet 5x10's: 150.50 MRP
VOMEC PLUS Beximco Pharmaceuticals Ltd Meclizine Hydrochloride USP 25mg + Pyridoxine Hydrochloride BP 50mg Tablet 50's: 150.00 MRP
XMEC Beacon Pharmaceuticals Limited Meclizine hydrochloride USP 25mg+ Pyridoxine hydrochloride BP 50mg Film Coated Tablet 50's: 150.50 MRP