mph Bangladesh


Procyclidine

(proe sye' kli deen) 

PCaution when used during lactation : Caution when used during pregnancy

LCaution when used during lactation : Caution when used during lactation

Molecule Info

| See TERMINOLOGY & ABBREVIATIONS |
Indication(s) & Dosage

Oral route
Parkinsonism and drug-induced extrapyramidal syndrome
Adult: As hydrochloride: Initially, 2.5 mg tid, increased gradually by 2.5-5 mg every 2-3 days if required. Maintenance: 10-30 mg/day in 3-4 divided doses. Up to 60 mg daily may be required in some cases. 
Elderly: Lower doses are required. 

Dystonia in children
Child: 7-12 yr: 1.25 mg tid; 12-18 yr: 2.5 mg tid. For emergency cases, a single dose may be given via IM or IV inj: <2 yr: 0.5-2 mg; 2-10 yr: 2-5 mg and 10-18 yr: 5-10 mg. 

Parenteral route
Parkinsonism and drug-induced extrapyramidal syndrome
Adult: Emergency cases: IV admin: 5-10 mg, higher doses may be needed; IM admin: 5-10 mg as a single dose, may repeat after 20 minutes if needed, to a max of 20 mg daily. 
Elderly: Lower doses are required.

Contraindications Urinary outflow obstruction, prostatic hyperthrophy, narrow-angle glaucoma, paralytic ileus and pyloric stenosis.
Special Precautions Patients with diarrhoea. May impair a patient's ability to perform skilled tasks e.g. driving. May precipitate psychotic episodes in patients with mental disorders. Thyrotoxicosis, heart failure, acute myocardial infarction, hypertension. Childn, elderly. Pregnancy and lactation. Avoid abrupt withdrawal.
Adverse Drug Reaction(s) Excitability, dizziness, hallucinations (seen on abuse), dry mouth, blurred vision, constipation, urinary retention, agitation, restlessness, confusion and convulsions.
Drug Interactions Increased plasma concentrations when used with paroxetine. May counteract the GI effects of cisapride, domperidone and metoclopramide. May also reduce gastric motility, thus affecting the absorption of other drugs.
Potentially Fatal: Additive anticholinergic effects with antihistamines, opiate antagonists, phenothiazine, tricyclic antidepressants, quinidine. Please consult detailed drug interactions before prescribing.
Pregnancy Category (FDA) Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Oral: Store at 15-25°C. Parenteral: Store at 15-25°C.
Pharmacology
 
Procyclidine is a tertiary amine antimuscarinic which acts by blocking excess acetylcholine at cerebral synapses. It also exhibits direct antispasmodic effect on smooth muscle.
Absorption: Bioavailability is about 75% after an oral dose.
Distribution: About one-fifth is metabolised in the liver, mainly by P450 isoenzymes.
Excretion: Mean elimination half-life: about 12 hr (oral and IV admin). A small amount of the drug is excreted unchanged in the urine.
ATC Classification N04AA04 - procyclidine; Belongs to the class of tertiary amines anticholinergic agents. Used in the management of parkinson's disease.

Brand/Product Info


Total Products : 7       
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
Cyclid Incepta Pharmaceuticals Limited Procyclidine Hydrochloride 5 mg Tablet 10x10's:MRP 100 Tk
Cyclid Injection Incepta Pharmaceuticals Limited Procyclidine Hydrochloride 10mg/2ml Injection Injection 1x1's:MRP 30 Tk
EXTRANIL General Pharmaceuticals Ltd Procyclidine hydrochloride 5mg Tablet 100's: 76.00 MRP
KDRINE Opsonin Pharma Limited Procyclidine hydrochloride 5mg Tablet 100's: 42.00 MRP
KEMADRIN GlaxoSmithKline Bangladesh Limited Procyclidine hydrochloride 5mg Tablet 100's: 186.20 MRP
PERKINIL 5 Square Pharmaceuticals Ltd. Procyclidine 5mg Tablet 10x20's: 200.00 MRP
PERKINIL INJ Square Pharmaceuticals Ltd. Procyclidine 10mg/2 ml IM/IV Injection 1x1's: 30.20 MRP

Gen. MedInfo

Why is Procyclidine prescribed?

Procyclidine is used to treat parkinsonism (slowed movements, stiffness of the body, uncontrollable body movements, weakness, tiredness, soft voice, and other symptoms caused by damaged nerves in the brain). Procyclidine is also used to treat problems with moving and drooling that may be caused by certain medications for mental illness. Procyclidine is in a class of medications called antispasmodics or antimuscarinics. It works by preventing sudden tightening of the muscles.

How should Procyclidine be used?

Procyclidine comes as a tablet to take by mouth. It is usually taken 3 times a day during or after meals and is sometimes also taken at bedtime. Take procyclidine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you do not understand. Take procyclidine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of procyclidine and gradually increase your dose.

Procyclidine may help control your symptoms but will not cure your condition. Continue to take procyclidine even if you feel well. Do not stop taking procyclidine without talking to your doctor.

Other uses for Procyclidine

Procyclidine may be prescribed for other uses; ask your doctor for more information.

What special precautions to follow?

Before taking procyclidine,

  • inform your doctor if you are allergic to procyclidine, any other medications, or any of the ingredients in procyclidine tablets. Ask your pharmacist for a list of the ingredients in procyclidine tablets.
  • inform your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • inform your doctor if you have or have ever had glaucoma (an eye disease), enlargement of the prostate (a male reproductive gland), low blood pressure, mental illness, fast or irregular heartbeat, ulcers, colitis (swelling of the intestine), difficulty urinating,or heart, kidney, liver, lung, nervous system, or thyroid disease.
  • inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking procyclidine, call your doctor.
  • you should know that procyclidine may make you drowsy or dizzy or cause blurred vision. Do not drive a car or operate machinery until you know how Procyclidine affects you.
  • you should know that procyclidine may make it harder for your body to cool down when it gets very hot. Drink plenty of fluids and be careful while exercising or participating in outside activities, especially in warm weather.

What special dietary instructions to follow?

Unless your doctor informs you otherwise, continue your normal diet.

What to do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can Procyclidine cause?

Procyclidine may cause side effects. inform your doctor if any of these symptoms are severe or do not go away:

  • dry mouth

  • widening of the pupils (black circle in the middle of the eye)

  • blurred vision

  • upset stomach

  • vomiting

  • stomach pain

  • constipation

  • giddiness

  • lightheadedness

  • muscle weakness

  • rash

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

  • confusion

  • disorientation

  • agitation

  • hallucinations (seeing things or hearing voices that do not exist)

  • fever

  • pain, swelling, redness, or hardness of the cheek

  • drainage of pus in the mouth

Procyclidine may cause other side effects. Call your doctor if you have any unusual problems while taking Procyclidine.

What to know about storage and disposal of Procyclidine?

Keep Procyclidine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

What other information to know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Procyclidine.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Ref: MedlinePLus, U.S. National Library of Medicine.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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