Donepezil

(doe nep' e zil) 

PCI / LCIContraindication for pregnancy & lactation (breast feeding)

Molecule Info

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Indication(s) & Dosage

DONEPEZIL indicated in-

Mild to moderately severe dementia in Alzheimer's disease
Adult: Initially, 5 mg daily at bedtime, increase if necessary up to 10 mg once daily at bedtime after 4-6 wk.
Elderly: Initially, 5 mg daily at bedtime, increase if necessary up to 10 mg once daily at bedtime after 4-6 wk.

Administration Should be taken on an empty stomach. Take 15-30 min before meals.
Overdosage Overdose may result in cholinergic crisis; symptoms include severe nausea, vomiting, salivation, hypotension, bradycardia, resp depression, collapse and seizures. Muscle weakness may increase and death may occur if resp muscles are involved. Treatment includes supportive measures and use of tertiary anticholinergics (such as atropine).
Contraindications Hypersensitivity.
Special Precautions Caution when used in patients with sick sinus syndrome or cardiac conduction abnormalities. May increase secretion of gastric acid; caution when used in patients at risk of ulcer disease. Patients with COPD, asthma, history of epilepsy, bladder obstruction, prostatic hypertrophy. May cause dose-related diarrhoea, nausea and/or vomiting which usually resolves after 1-3 wk. Safety and efficacy have not been established in children. Pregnancy, lactation.
Adverse Drug Reactions Nausea, vomiting, anorexia, wt loss, diarrhoea, insomnia, fatigue, muscle cramps; headache and dizziness; syncope, bradycardia; convulsions; increased liver transaminases; sinoatrial and atrioventricular block; hallucinations, agitation and aggressive behavior; minor increases in plasma creatine kinase; potentially bladder outflow obstruction.
Drug Interactions May increase the neurotoxic effect of antipsychotics. Concurrent use with systemic corticosteroids may increase the adverse effects of donepezil. May increase the neuromuscular-blocking effect of succinylcholine. May increase the adverse effects of cholinergic agonists. May increase the bradycardic effect of Beta-blockers. Please consult detailed drug interactions before prescribing.
Food Interaction Ginkgo biloba may increase the adverse effects of donepezil.
Pregnancy Category (FDA)  Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Oral: Store below 30°C.
Pharmacology
Donepezil reversibly and noncompetitively inhibits centrally-active acetylcholinesterase. It is used for the symptomatic treatment of Alzheimer's disease.
Absorption: Well absorbed in the GI tract. Plasma levels peak within 3-4 hr after oral admin.
Distribution: Protein binding: About 95% (mainly albumin).
Metabolism: Partially metabolised in the liver mainly by CYP3A4 to 4 major metabolites.
Excretion: Elimination half-life: About 70 hr. Steady-state concentrations are achieved within 3 wk of treatment initiation.
ATC Classification N06DA02 - donepezil; Belongs to the class of anticholinesterases. Used in the management of dementia.

Brand/Product Info


Total Products : 2  
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
Ameloss 5 Incepta Pharmaceuticals Limited Each film coated tablet contains Donepezil Hydrochloride INN 5 mg Tablet 10x3's:MRP 300 Tk
ELZER Square Pharmaceuticals Ltd. Donepezil 5mg Tablet 5x6's: 302.10 MRP

Gen. MedInfo

Why is Donepezil prescribed?

Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) associated with Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, social interaction, reasoning and language abilities, and ability to perform activities of daily living) by increasing the amount of a certain naturally occurring substance in the brain. Donepezil may improve the ability to think and remember or slow the loss of these abilities in people who have AD. However, donepezil will not cure AD or prevent the loss of mental abilities at some time in the future.

How should Donepezil be used?

Donepezil comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken once a day, in the evening at bedtime, with or without food. Take donepezil at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. It may take awhile before you experience the full benefits of donepezil. Take donepezil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Donepezil helps control the symptoms of Alzheimer's disease but does not cure it. Continue to take donepezil even if you feel well. Do not stop taking donepezil without talking to your doctor.

Your doctor may start you on a low dose of donepezil and increase your dose after 4 to 6 weeks.

To take the orally disintegrating tablet, place the tablet on your tongue. The tablet will quickly dissolve and can be followed with a drink of water.

Other uses for Donepezil

Donepezil may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions to follow?

Before taking donepezil,

  • inform your doctor if you are allergic to donepezil or any other medications.
  • inform your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen; bethanechol; carbamazepine (Tegretol); dexamethasone; ipratropium; ketoconazole (Nizoral); medications for glaucoma, irritable bowel disease, motion sickness, myasthenia gravis, Parkinson's disease, ulcers, or urinary problems; phenobarbital; phenytoin; quinidine; and rifampin (Rifadin, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • inform your doctor if you have or have ever had gastrointestinal (GI) bleeding; an ulcer,asthma, or obstructive pulmonary disease (chronic bronchitis or emphysema), or heart disease.
  • inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking donepezil, call your doctor.
  • if you are having surgery, including dental surgery, inform the doctor or dentist that you are taking donepezil.

What special dietary instructions to follow? 

Unless your doctor informs you otherwise, continue your normal diet.

What to do if I forget a dose?

If you forget to take a dose of donepezil, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you do not take donepezil, for 1 week or longer, you should call your doctor before starting to take Donepezil again.

What side effects can Donepezil cause?

Donepezil may cause side effects. inform your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • vomiting

  • diarrhea

  • loss of appetite

  • weight loss

  • frequent urination

  • muscle cramps

  • joint pain, swelling, or stiffness

  • pain

  • excessive tiredness

  • drowsiness

  • headache

  • dizziness

  • nervousness

  • depression

  • confusion

  • changes in behavior

  • abnormal dreams

  • difficulty falling asleep or staying asleep

  • discoloration or bruising of the skin

  • red, scaling, itchy skin

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
  • fainting

  • slow heartbeat

  • chest pain

  • black or tarry stools

  • red blood in stools

  • bloody vomit

  • vomit that looks like coffee grounds

  • inability to control urination

  • difficulty urinating or pain when urinating

  • lower back pain

  • fever

  • seizures

Donepezil may cause other side effects. Call your doctor if you have any unusual problems while taking Donepezil.

What to know about storage and disposal of Donepezil?

Keep Donepezil in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose 

In case of overdose, consult your doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.

Symptoms of overdose may include:

  • nausea

  • vomiting

  • drooling

  • sweating

  • slow heartbeat

  • difficulty breathing

  • muscle weakness

  • fainting

  • seizures

What other information to know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Donepezil.

Do not let anyone else use your medication. If you still have symptoms and need further treatment, consult your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

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