Flupenthixol  (Flupentixol) + Melitracen

Molecule Info

 
Indication & Dosage Oral
Depression
Adult: Per tablet contains Flupentixol/Flupenthixol 0.5 mg and melitracen 10 mg: 1 tablet in the morning and at midday. May double morning dose in severe cases. Not to exceed 4 tablets daily. 
Elderly: Per tablet contains flupentixol 0.5 mg and melitracen 10 mg: 1 tablet in the morning. For severe cases: 1 tablet in the morning and at midday.
Administration Normal release prep: May be taken with or without food. Admin instructions for modified release prep may vary according to brands, refer to lit.
Contraindications Circulatory collapse, depressed level of consciousness due to any cause, coma. Severe depressing requiring hospitalisation or electroconvulsive therapy. Not recommended for use in states of excitement or overactivity.
Special Precautions Unsafe in porphyria. Caution when used in patients with epilepsy; Parkinson's disease; narrow angle glaucoma; prostatic hypertrophy; hypothyroidism; hyperthyroidism; liver disease; cardiac disease or arrhythmias; severe respiratory disease; renal failure; myasthenia gravis; phaeochromocytoma. Patients with hypersensitivity to thioxanthenes or other antipsychotics. Close monitoring for changes in behaviour, suicidal thoughts or clinical worsening during the initial part of the treatment is recommended. May impair control of diabetes; monitor blood glucose in diabetics. Withdrawal should be gradual.
Adverse Drug Reactions Drowsiness, dry mouth, constipation, vomiting, dyspepsia, diarrhoea, abdominal pain, nausea, flatulence. Extrapyramidal effects, especially in the initial phase of the treatment. Tachycardia, palpitations, prolonged QT interval, hypotension. Thrombocytopenia, neutropenia, leukopenia, agranulocytosis. Dyspnoea, myalgia, muscle rigidity, micturition disorder, urinary retention. Increased appetite and wt. Abnormal glucose tolerance and LFTs. Insomnia, depression, nervousness, agitation, libido decreased.
Drug Interactions Increased risk of adverse effects when used with alcohol. May potentiate the effects of general anaesthetics and anticoagulants, and prolong the action of neuromuscular blockers. May increase anticholinergic effects of atropine and drugs with anticholinergic activity. May increase risk of neurotoxicity when used with sibutramine or lithium. Avoid concurrent usage with drugs that cause QT prolongation or cardiac arrhythmias. May inhibit metabolism of TCAs. May antagonise effects of adrenaline and sympathomimetics, and reverse antihypertensive effects of guanethidine. Please consult detailed drug interactions before prescribing.
Pharmacology Flupentixol inhibits dopamine-mediated effects by blocking postsynaptic dopamine receptors in the CNS. Melitracen is a TCA with anxiolytic properties. At low doses, it has activating properties. It is also a bipolar thymoleptic.
Absorption: Flupentixol/Flupenthixol: Readily absorbed in the GI tract.
Distribution: Flupentixol/Flupenthixol: >95% bound to plasma proteins; widely distributed in the body and crosses the blood brain barrier.
Metabolism: Flupentixol/Flupenthixol: Extensively hepatic metabolism.
Excretion: Flupentixol/Flupenthixol: Excreted in urine and faeces in the form of many metabolites.
ATC Classification N05AF01 - flupentixol/flupenthixol; Belongs to the class of thioxanthene derivatives antipsychotics. Used in the management of psychosis. 
N06AA14 - melitracen; Belongs to the class of non-selective monoamine reuptake inhibitors. Used in the management of depression.

Brand/Product Info


Total Products : 51                                                   
Brand Name Manufacturer/Marketer Composition Dosage Form Pack Size & Price
AMILAX Amico Laboratories Ltd. Flupenthixol Dihydrochloride INN 0.5mg + Melitracen Hydrochloride INN 10mg Tablet 50's: 160.00 MRP
ANFREE Aristopharma Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 100's: 360.00 MRP
ANGENTA Healthcare Pharmacuticals Ltd. Flupenthixol Dihydrochloride 500mcg + Melitracen Hydrochloride 10mg Tablet 100's MRP 400 Tk
ANGENTA Doctors Chemical Works Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
ANTISON Asiatic Laboratories Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 30's: 150.00 MRP
ANZET Popular Pharmaceuticals Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's, 100's: 175.50 & 351.00 IP
BENZIT Biopharma Laboratories Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 100's: 351.00 MRP
BP-XIT Bristol Pharma Limited Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 100's: 350.00 MRP
DEANXIT Lundbeck/Lilac Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 100's: 550.00 MRP
DELETA General Pharmaceuticals Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.50 MRP
DEPRESIL Rangs Pharmaceuticals Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 162.50 MRP
DEXIT Unimed & Unihealth Manufacturers Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
DICONTEN Drug International Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 200.00 MRP
DINXI Chemist Laboratories Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 150.00 MRP
DORMIR Somatec Pharmaceuticals Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.50 MRP
EXILOR Sun Pharmaceutical (Bangladesh) Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
EXUTEN Pharmadesh Laboratories Limited Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 30's: 105.30 MRP
FEMANOL Kemiko Pharmaceuticals Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 200.00 MRP
FEMIXIT Monico Pharma Limited Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
FLUXIT Opsonin Pharma Limited Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.50 MRP
FMR R A K Pharmaceuticals Pvt. Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
FRAXIT Pharmasia Limited Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.50 MRP
FRENXIT Beximco Pharmaceuticals Ltd Flupenthixol Dihydrochloride 500mcg + Melitracen Hydrochloride 10mg Tablet 150's: 750.00 MRP
FREXIT Asiatic Laboratories Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 30's: 105.00 MRP
HENXIT Hudson Pharmaceuticals Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 100's: 350.00 MRP
INSPRA Medicon Laboratories Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
LEANXIT The Acme Laboratories Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 100's: 350.00 MRP
LUMEXIT Kumudini Pharma Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
MELIXOL Square Pharmaceuticals Ltd. Flupenthixol 0.5mg + Melitracen 10mg Tablet 5x10's: 251.00 MRP
MELTIX Navana Pharmaceuticals Limited Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.50 MRP
MELXIT Ziska Pharmaceuticals Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
MIXIT Apex Pharmaceuticals Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
NEOXIT Novo Healthcare and Pharma Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 30's: 105.00 MRP
PENTIXOL Techno Drugs Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 30's: 90.00 MRP
PENXIT Peoples Pharma Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 130.00 MRP
RADEX Globe Pharmaceuticals Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 30's: 105.00 MRP
RELUX Rephco Laboratories Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 150.00 MRP
REMOOD IBN SINA Pharmaceutical Industry Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 200.00 MRP
RENXIT Renata Limited Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 100's: 351.00 MRP
SENSIT Eskayef Bangladesh Ltd Flupenthixol Dihydrochloride BP 0.5mg + Melitracen Hydrochloride INN 10mg Tablet (film-coated) 50's MRP: 175.00
STIMO Delta Pharma Limited Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
Tenaxit Incepta Pharmaceuticals Limited Flupenthixol Dihydrochloride 500mcg + Melitracen Hydrochloride 10mg Tablet 10x5's:MRP 175 Tk
TENSA Shamsul Alamin Pharmaceuticals Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
TENSICON The White Horse Pharma Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
THENXET Pacific Pharmaceuticals Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 100's: 400.00 MRP
TIXOCIN Sharif Pharmaceuticals Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 30's: 105.00 MRP
TIXOL Alco Pharma Ltd Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 150.00 MRP
U4 Orion Pharma Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.50 MRP
XIT Everest Pharmaceuticals Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
XOLITRA Beacon Pharmaceuticals Limited Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 50's: 175.00 MRP
ZENXIT Zenith Pharmaceuticals Ltd. Flupenthixol Dihydrochloride 0.5mg + Melitracen Hydrochloride 10mg Tablet 100's: 325.00 MRP