Phentermine and diethylpropion are central stimulants; they are not recommended for the treatment of obesity. Phentermine has been associated with a risk of pulmonary hypertension.

Sibutramine, dexfenfluramine, and fenfluramine have been withdrawn because the benefit of treatment does not outweigh the risk of serious adverse effects.

Herbal & Nutraceuticals are food or part of food that provides medical or health benefits including the prevention and/or treatment of a disease. They have advantage over the medicine because they avoid side effect, have naturally dietary supplement, etc. Nutraceutical; on the basis of their natural source,
chemical grouping, categories into three key terms -nutrients, herbals, dietary supplements, dietary fiber, etc.